Phenazines and Other Redox-Active Antibiotics Promote Microbial Mineral Reduction

Phenazines and other redox-active antibiotics promote microbial mineral reduction.

Natural products with important therapeutic properties are known to be produced by a variety of soil bacteria, yet the ecological function of these compounds is not well understood. Here we show that phenazines and other redox-active antibiotics can promote microbial mineral reduction. Pseudomonas chlororaphis PCL1391, a root isolate that produces phenazine-1-carboxamide (PCN), is able to reduc...

Microbial mineral colonization across a subsurface redox transition zone

This study employed 16S rRNA gene amplicon pyrosequencing to examine the hypothesis that chemolithotrophic Fe(II)-oxidizing bacteria (FeOB) would preferentially colonize the Fe(II)-bearing mineral biotite compared to quartz sand when the minerals were incubated in situ within a subsurface redox transition zone (RTZ) at the Hanford 300 Area site in Richland, WA, USA. The work was motivated by th...

Consequences of redox - active phenazines on the physiology of the opportunistic pathogen Pseudomonas aeruginosa by

Penicillin and Other Antibiotics

Microbial transformations of antibiotics.

In spite of their unusual molecular structures and seemingly high degree of biological recalcitrance, many antibiotics have been shown to be susceptible to microbial attack. Among the types of changes brought about by microbial systems are: (i) acylation; (ii) phosphorylation; (iii) adenylylation and ribonucleotide formation; (iv) hydrolysis; (v) oxidation; (vi) suiph oxidation; (vii) reduction...